Advanced Design Optimization

CFD/Hemolysis

One of the most important tasks in the development of ventricular assist devices (VADs)  and other medical devices delivering blood is to minimize the shear-induced blood trauma (hemolysis) to guarantee a good biocompatibility. Various numerical blood damage models integrated into our CFD/FEA-based design optimization tool allow us to quickly and accurately evaluate the hemolysis. This will greatly shorten the design cycle for the development of a biocompatible VAD or medical device. We can use either Lagrangian particle tracking technology or Eulerian methods to evaluate the blood damage depending on the conditions. Our method is further strengthened by the detailed breakdown analysis of regional contributions to the overall blood damage. This regional analysis is very useful by providing insights into which components contribute most to the hemolysis level and therefore invite focused optimization.

Technology
Blood Pumps
Green Energy
Optimization Cases
Mesh Generation
Steady-State
Transient
Hemolysis
CFD
FEA
FSI
Exposure Time Numerical hemolysis index

Shear stress history for the first generation of PediaFlow (PF1) by Lagrangian method. ( Please see Ref. [2] )

 
Portion of total blood damage contributed by different pump components over the entire flow region
Twitter Facebook_LOGO Youtube_Logo LinkedinLOGO
|
|
|
|
Contact Us
Terms of Use
Privacy Policy
Copyright © 2018 Advanced Design Optimization LLC. All rights reserved.